Historical Control Data of the Japan
نویسنده
چکیده
3 About tetrachloroethylene 7 I Study materials I-1 Study sample lots, etc .. 14 I-2 Identity, stability of study sample 14 I -2-1. Identity 14 I-2-2 Stability 14 I-3 Laboratory animals 14 II Study methods IIL Administration II-1-1 Administration route, administration method, and administration period 15 II-1-2. Administration concentration and reason for establishing the same 15 II-1-3 Method ofgenerating and adjusting concentration of study sample 15 II-1-4. Determination of concentration of study sample 17 ll-2 Animal management II-2-L Grouping and individual identification methods 17 II-2-2 Rearing conditions 17 II-3. Observation and test items and methods II-3L Observation of general stahrs of animals 21 II-3-2. Body weight detennination 21 II-3-3. Food consumption detennination 21 II-3-4. Hematological tests 21 II-3-5 Blood chemistry tests 21 II-3-6. Urinalyses 21 II-3-7 Pathological tests 21 II-4 Numerical treatment and statistical methods (1) Handling and representation of numbers 22 (2) Handling and representation of parameters 22 (3) Statistical methods 23 III Study results III-I Carcinogenicity studies using rats (1) Observation of animal status 24 (2) Hematological tests, blood chemistry tests, urinalyses 25 (3) Pathological tests 29 III-2 Carcinogenicity studies using mice (I) Observation of animal status 33 (2) Hematological tests, blood chemistry tests, urinalyses 34 (3) Pathological tests 38 IV.. Discussion 46
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تاریخ انتشار 2006